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Doxycycline is used for many different types of infections, including respiratory tract infections due to Streptococcus pneumonia, Hemophilus influenzae, or Mycoplasma pneumoniae. It also is used for the treatment of nongonococcal urethritis Rocky mountain spotted fever, brucellosis, chancroid, cholera, brucellosis, anthrax, syphilis, and acne.
The absorption of doxycycline is not particularly affected by food, and therefore, it can be taken with meals. For most infections, doxycycline is administered once or twice daily for 7 to 14 days. For adult infections, the normal dose of oral doxycycline is 200 mg on the first day of treatment (100 mg every 12 hours) followed by a dose of 100 mg/day as a single dose or 50 mg twice daily.
It is recommended that doxycycline not be taken at the same time as aluminum, magnesium, or calcium based antacids, such as Maalox, Mylanta, Tums, or Rolaids because, like food, these medications bind doxycycline in the intestine and prevent its absorption. Similarly, doxycycline should not be taken with minerals (such as iron or calcium) or with bismuth subsalicylate.
Doxycycline may enhance the activity of warfarin and cause excessive "thinning" of the blood leading to exaggerated bleeding, necessitating a reduction in the dose of warfarin. Phenytoin, carbamazepine, and barbiturates may enhance the metabolism (destruction) of doxycycline thus making it less effective.
Tetracycline antibiotics, including doxycycline, can have toxic effects on development of bone in the fetus. Therefore, tetracyclines are not highly recommended during pregnancy unless there is no other appropriate antibiotic.
This drug is secreted into breast milk but the extent of absorption by the breastfed infant is not known. Since tetracyclines can cause negative effects on bone, the use of tetracyclines in nursing mothers is of concern. The doctor must decide whether to recommend that a nursing mother discontinue nursing during treatment with tetracyclines or change to a different antibiotic.
SIDE EFFECTS: Doxycycline is generally well-tolerated. The most common side effects are diarrhea or loose stools, nausea, abdominal pain, and vomiting. Tetracyclines, such as doxycycline, may cause tooth discoloration if used in persons below 8 years of age. Exaggerated sunburn can occur with tetracyclines; therefore, sunlight should be minimized during treatment.